Chemistry A Molecular Approach Chemistry Chemistry

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Chemical Biology of Neurodegeneration

Chemical Biology of Neurodegeneration Pdf/ePub eBook Author: Pedro Merino
Editor: John Wiley & Sons
ISBN: 3527813438
FileSize: 1604kb
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Chemical Biology of Neurodegeneration by Pedro Merino Summary

Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents. -Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.

Oncle Tungstène

Oncle Tungstène Pdf/ePub eBook Author: Oliver Sacks
Editor: Média Diffusion
ISBN: 2021411974
FileSize: 1303kb
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Oncle Tungstène by Oliver Sacks Summary

Oliver Sacks a toujours exploré la richesse inédite de l'expérience humaine à travers des récits de cas. C'est avec la même curiosité et le même désir de comprendre qu'il se penche dans ce livre sur l'enfant qu'il a été, et la passion qu'il a éprouvée pour la chimie. Il évoque son enfance dans l'Angleterre de la guerre, au sein d'une famille de scientifiques, et sa fascination précoce pour les métaux. Puis ce sont les années de pensionnat, sans bonheur, mais où se développe le goût de l'exploration intellectuelle qui devait marquer sa vie entière. Enfin le retour à Londres, où l'enfant, privé d'affection, trouvera un réconfort dans le jardin secret de la chimie, qui lui parle des métaux, des gaz, des éléments, de la matière et de l'ordre caché des choses. Oncle Tunsgtène raconte l'histoire d'un enchantement et la façon dont il a façonné une vie: la science est unie à l'enfance par un lien essentiel - elle en tire sa profondeur humaine et sa poésie.

Molecular Electromagnetism: A Computational Chemistry Approach

Molecular Electromagnetism: A Computational Chemistry Approach Pdf/ePub eBook Author: Stephan P. A. Sauer
Editor: OUP Oxford
ISBN: 0191621005
FileSize: 1838kb
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Molecular Electromagnetism: A Computational Chemistry Approach by Stephan P. A. Sauer Summary

This is a textbook on the theory and calculation of molecular electromagnetic and spectroscopic properties designed for a one-semester course with lectures and exercise classes. The idea of the book is to provide thorough background knowledge for the calculation of electromagnetic and spectroscopic properties of molecules with modern quantum chemical software packages. The book covers the derivation of the molecular Hamiltonian in the presence of electromagnetic fields, and of time-independent and time-dependent perturbation theory in the form of response theory. It defines many molecular properties and spectral parameters and gives an introduction to modern computational chemistry methods.

Introduction to Bioorganic Chemistry and Chemical Biology

Introduction to Bioorganic Chemistry and Chemical Biology Pdf/ePub eBook Author: David Van Vranken,Gregory A. Weiss
Editor: Garland Science
ISBN: 1135054827
FileSize: 1485kb
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Introduction to Bioorganic Chemistry and Chemical Biology by David Van Vranken,Gregory A. Weiss Summary

Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.