Download Tim Lincecum Pdf

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A Band of Misfits

A Band of Misfits Pdf/ePub eBook Author:
Editor: Triumph Books
ISBN: 1633192377
FileSize: 1771kb
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A Band of Misfits by Summary

With a title drought that started in New York and carried on for more than five decades after the move to the west coast, the San Francisco Giants and their fans were growing restless, waiting for a team like the 2010 roster and that one magical postseason run. The anticipation, memories, and celebrated relief of the season when it finally came together are captured in this chronicle of the World Series season of the Giants. Written in entertaining prose, the book is as much an enjoyable story to be reread through the years as it is a factual account of the events that brought the elusive title to the Giants.

The Mood Guide to Fabric and Fashion

The Mood Guide to Fabric and Fashion Pdf/ePub eBook Author: Mood Designer Fabrics
Editor: Abrams
ISBN: 161312872X
FileSize: 592kb
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The Mood Guide to Fabric and Fashion by Mood Designer Fabrics Summary

“Designers, we’re going to Mood!” More than 10 years ago, Tim Gunn and Project Runway introduced millions of viewers to New York’s ultimate fabric mecca, Mood Fabrics. Now, the experts behind this fabric power- house bring their fabric and fashion know-how—plus their behind-the-scenes stories—to the sewing public. The Mood Guide to Fabric and Fashion is the ultimate guide for home-sewers, fashion students, aspiring designers, and Project Runway fans who want to learn everything they need to know to choose and use quality fabric. Drawing upon the expertise of the Mood staff, the book teaches readers the fundamentals—from where fabric is produced to the ins and outs of its construction—and features a fabric-by-fabric guide to cottons and other plant fibers, wools, silks, knits, and other specialty fabrics.

Find It, Fix It, Flip It!

Find It, Fix It, Flip It! Pdf/ePub eBook Author: Michael Corbett
Editor: Penguin
ISBN: 1101219408
FileSize: 420kb
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Find It, Fix It, Flip It! by Michael Corbett Summary

“Shows us how to turn passion into profit."—Tony Robbins, bestselling author of Awaken the Giant Within Michael Corbett—host of Extra’s Mansions and Millionaires—shares his strategies, tips, and never-before-revealed insider techniques that have helped him make a fortune in real estate. This book is for aspiring flippers, first-time home buyers, or any homeowner who wants to create big profits and own their ultimate dream home—mortgage free! Starting with the essentials, Corbett shares how to crunch the numbers to instantly determine a house’s profit potential. He then covers every step from purchase to sale: • Get the profit-making house at the price you can afford • Make the improvements that make you millions • Insider secrets that save you thousands • Take advantage of the market’s ups and downs • Sell your home tax free and pocket the profits Filled with practical tips, illustrated with before-and-after case studies and easy to use charts and worksheets, Find It, Fix It, Flip It! offers the insider expertise needed to tap into an exciting—and potentially limitless—new source of income and financial independence.

Trading Bases

Trading Bases Pdf/ePub eBook Author: Joe Peta
Editor: Penguin
ISBN: 1101609656
FileSize: 934kb
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Trading Bases by Joe Peta Summary

An ex–Wall Street trader improved on Moneyball’s famed sabermetrics and beat the Vegas odds with his own betting methods. Here is the story of how Joe Peta turned fantasy baseball into a dream come true. Joe Peta turned his back on his Wall Street trading career to pursue an ingenious—and incredibly risky—dream. He would apply his risk-analysis skills to Major League Baseball, and treat the sport like the S&P 500. In Trading Bases, Peta takes us on his journey from the ballpark in San Francisco to the trading floors and baseball bars of New York and the sportsbooks of Las Vegas, telling the story of how he created a baseball “hedge fund” with an astounding 41 percent return in his first year. And he explains the unique methods he developed. Along the way, Peta provides insight into the Wall Street crisis he managed to escape: the fragility of the midnineties investment model; the disgraced former CEO of Lehman Brothers, who recruited Peta; and the high-adrenaline atmosphere where million-dollar sports-betting pools were common.

The Subcommissural Organ

The Subcommissural Organ Pdf/ePub eBook Author: Andreas Oksche,Esteban M. Rodriguez,Pedro Fernandez-Llebrez
Editor: Springer Science & Business Media
ISBN: 364278013X
FileSize: 1299kb
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The Subcommissural Organ by Andreas Oksche,Esteban M. Rodriguez,Pedro Fernandez-Llebrez Summary

The subcommissural organ is a secretory ependymo-glial structure of the brain. It secretes glycoproteins into the crebrospinal fluid. The chemical nature of this material is only partly known, and the functional role of theentire circumventricular complex has remained enigmatic. New experimental models include transplantation, immunological blockade,and experimental and clinical hydrocephalus. This first book in the field containing provocative ideas will most likely stimulate further investigations into molecular and systemic aspects of the problem.

Car PC Hacks

Car PC Hacks Pdf/ePub eBook Author: Damien Stolarz
Editor: \"O\'Reilly Media, Inc.\"
ISBN: 0596553129
FileSize: 1393kb
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Car PC Hacks by Damien Stolarz Summary

A car PC or carputer is a car tricked-out with electronics for playing radio, music and DVD movies, connecting to the Internet, navigating and tracking with satellite, taking photos, and any electronic gadget a person wants in a car. All these devices are managed and controlled through a single screen or interface. The only place car PC enthusiasts can go for advice, tips and tools is a handful of hard-to-find Web sites--until now. Car PC Hacks is your guide into the car PC revolution.Packing MP3 players, handheld devices, computers and video-on-demand systems gives you a pile too heavy to carry. But add a car and put them together, you've got a powerful and mobile multimedia center requiring no lifting. The next time you give kids a lift, you won't hear, "Are we there yet?" Instead, expect "We're there already?" as they won't want to leave the car while playing video games from multiple consoles.Car PC Hacks is the first book available to introduce and entrench you into this hot new market. You can count on the book because it hails from O'Reilly, a trusted resource for technical books. Expect innovation, useful tools, and fun experiments that you've come to expect from O'Reilly's Hacks Series.Maybe you've hacked computers and gadgets, and now you're ready to take it to your car. If hacking is new and you would like to mix cars and computers, this book gets you started with its introduction to the basics of car electrical systems. Even when you're unclear on the difference between amps and watts, expect a clear explanation along with real-life examples to get on track. Whether you're venturing into car PC for the first time or an experienced hobbyist, hop in the book for a joy ride.

Marine Niche: Applications in Pharmaceutical Sciences

Marine Niche: Applications in Pharmaceutical Sciences Pdf/ePub eBook Author: Neelam M Nathani,Chandrashekar Mootapally,Indra R. Gadhvi,Bharat Maitreya,Chaitanya G. Joshi
Editor: Springer Nature
ISBN: 9811550174
FileSize: 696kb
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Marine Niche: Applications in Pharmaceutical Sciences by Neelam M Nathani,Chandrashekar Mootapally,Indra R. Gadhvi,Bharat Maitreya,Chaitanya G. Joshi Summary

This book offers a comprehensive study of biological molecules acquired from marine organisms, which have been exploited for drug discovery with the aim to treat human diseases. Biomolecules have potential impacts on a diverse range of fields, including medical and pharmaceutical science, industrial science, biotechnology, basic research, molecular science, environmental science and climate change, etc. To understand and effectively apply medicinally important biomolecules, multidisciplinary approaches are called for. The ocean remains a rich biological resource, and the vast untapped potential of novel molecules from marine bio-resources has caught the interest of more and more researchers. These novel biological compounds have never been found in terrestrial or other ecosystems, but only in this rich niche. Advances in sampling techniques and technologies, along with increased funding for research and nature conservation, have now encouraged scientists to look deeper in the waters. Aquaculture supports both tremendous seafood production and the bulk production of marine-derived drugs. Furthermore, molecular methods are now being extensively employed to explore the untapped marine microbial diversity. With the help of molecular and biotech tools, the ability of marine organisms to produce new biosynthetic drugs can be greatly enhanced. This book provides an extensive compilation of the latest information on marine resources and their undisputedly vital role in the treatment of diverse ailments.

Managing Type 2 Diabetes For Dummies

Managing Type 2 Diabetes For Dummies Pdf/ePub eBook Author: American Diabetes Association
Editor: John Wiley & Sons
ISBN: 1119363306
FileSize: 1008kb
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Managing Type 2 Diabetes For Dummies by American Diabetes Association Summary

Discover how to manage diabetes for a healthier and happier life! Written for anyone diagnosed with type 2 diabetes (and for anyone who loves someone with diabetes), Managing Type 2 Diabetes For Dummies is an essential guide to understanding the effects of diabetes and knowing what steps to take to successfully manage this chronic illness. Diabetes can lead to serious complications but people with diabetes can control the condition and lower the risk of its many complications. This is your easy-to-understand guide that shows you how. Under the direction of The American Diabetes Association, Managing Type 2 Diabetes For Dummies gives hope to the one in 11 people in the United States who are affected by the disease. Written in simple-to-understand terms, Managing Type 2 Diabetes For Dummies is filled with a wealth of expert advice and includes the most current information on recent medical advances for treatment. Improperly managed diabetes and consistently high blood glucose levels can lead to serious diseases affecting the heart and blood vessels, eyes, kidneys, nerves, and teeth. With the authorities at the American Diabetes Association on your side, you will have a practical handbook for preventing complications and managing diabetes with confidence! Prevent and manage the complications of the disease Combat diabetes-related anxiety and depression Lead a healthy life with type 2 diabetes Tap into the better living “rules of the road” with Managing Type 2 Diabetes For Dummies. By modifying your diet, consulting with your doctors, staying active, and understanding what medications are right for you, you will be on the path to a happier and healthier lifestyle.

Mechanosensitivity and Mechanotransduction

Mechanosensitivity and Mechanotransduction Pdf/ePub eBook Author: Irina Kiseleva,Andre Kamkin
Editor: Springer Science & Business Media
ISBN: 9789048198818
FileSize: 1648kb
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Mechanosensitivity and Mechanotransduction by Irina Kiseleva,Andre Kamkin Summary

This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Chemistry and Biology of Heparin and Heparan Sulfate

Chemistry and Biology of Heparin and Heparan Sulfate Pdf/ePub eBook Author: Hari G. Garg,Robert J. Linhardt,Charles A. Hales
Editor: Elsevier
ISBN: 9780080529059
FileSize: 1154kb
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Chemistry and Biology of Heparin and Heparan Sulfate by Hari G. Garg,Robert J. Linhardt,Charles A. Hales Summary

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. Comprehensively reviews all aspects of heparin and heparan sulfate research Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

Curveball

Curveball Pdf/ePub eBook Author: Barry Zito
Editor: Thomas Nelson
ISBN: 0785227881
FileSize: 458kb
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Curveball by Barry Zito Summary

In 2007, pitcher Barry Zito signed a seven-year, $126 million contract with the San Francisco Giants. At that time, it was the largest contract ever given to a pitcher. He was at the top of his game, in peak physical condition, and had the kind of financial security most people can only dream of. He was also miserable. And it began to show. Zito’s career declined over the next few years until he hit rock bottom—watching from the bench as his team won the World Series in 2010. In the months that followed, Zito came face-to-face with the destructiveness of his own ego—his need to be viewed as the best. He also came face-to-face with God and with the truth that he was loved no matter what he achieved. In Curveball, Zito shares his story with honesty and transparency. The ups and the downs. The wins and losses. By sharing his experiences as a man who had everything except happiness, Zito offers readers a path through adversity and toward a life defined by true success.

Little Manila Is in the Heart

Little Manila Is in the Heart Pdf/ePub eBook Author: Dawn Bohulano Mabalon
Editor: Duke University Press
ISBN: 0822395746
FileSize: 1868kb
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Little Manila Is in the Heart by Dawn Bohulano Mabalon Summary

In the early twentieth century—not long after 1898, when the United States claimed the Philippines as an American colony—Filipinas/os became a vital part of the agricultural economy of California's fertile San Joaquin Delta. In downtown Stockton, they created Little Manila, a vibrant community of hotels, pool halls, dance halls, restaurants, grocery stores, churches, union halls, and barbershops. Little Manila was home to the largest community of Filipinas/os outside of the Philippines until the neighborhood was decimated by urban redevelopment in the 1960s. Narrating a history spanning much of the twentieth century, Dawn Bohulano Mabalon traces the growth of Stockton's Filipina/o American community, the birth and eventual destruction of Little Manila, and recent efforts to remember and preserve it. Mabalon draws on oral histories, newspapers, photographs, personal archives, and her own family's history in Stockton. She reveals how Filipina/o immigrants created a community and ethnic culture shaped by their identities as colonial subjects of the United States, their racialization in Stockton as brown people, and their collective experiences in the fields and in the Little Manila neighborhood. In the process, Mabalon places Filipinas/os at the center of the development of California agriculture and the urban West.

The Neyer/James Guide to Pitchers

The Neyer/James Guide to Pitchers Pdf/ePub eBook Author: Bill James,Rob Neyer
Editor: Simon and Schuster
ISBN: 1439103771
FileSize: 529kb
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The Neyer/James Guide to Pitchers by Bill James,Rob Neyer Summary

Pitchers, the pitches they throw, and how they throw them -- these days it's the stuff of constant scrutiny, but there's never been anything like a comprehensive source for such information. That's what preeminent baseball analyst Bill James and ESPN.com baseball columnist Rob Neyer realized over lunch more than a dozen years ago. Since then, they've been compiling the centerpiece of this book, the "Pitcher Census," which lists specific information for nearly two thousand pitchers, ranging throughout the history of professional baseball. The Guide also offers: A "dictionary" describing virtually every known pitch The origins and development of baseball's most important pitches Top ten lists: best fastballs, best spitballs, and everything in between Biographies of some of the great pitchers who have been overlooked More knuckleballers and submariners than you ever thought existed An open debate concerning pitcher abuse and durability A formula for predicting the Cy Young Award winner Something fresh and new: Bill James' "Pitcher Codes" The Neyer/James Guide to Pitchers is about understanding pitchers, and baseball's action always starts with the pitchers. It's also about entertaining debates and having a great deal of fun with the history of a game that obsesses so many.

Wherever I Wind Up

Wherever I Wind Up Pdf/ePub eBook Author: R.A. Dickey
Editor: Penguin
ISBN: 1101561149
FileSize: 360kb
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Wherever I Wind Up by R.A. Dickey Summary

The perfect gift for baseball fans, now with a new epilogue by author R.A. Dickey, winner of the 2012 Cy Young award. "An astounding memoir—haunting and touching, courageous and wise."—Jeremy Schaap, bestselling author, Emmy award-winning journalist, ESPN In 1996, R.A. Dickey was the Texas Rangers’ much-heralded No. 1 draft choice. Then, a routine physical revealed that his right elbow was missing its ulnar collateral ligament, and his lifelong dream—along with his $810,000 signing bonus—was ripped away. Yet, despite twice being consigned to baseball’s scrap heap, Dickey battled back. Sustained by his Christian faith, the love of his wife and children, and a relentless quest for self-awareness, Dickey is now the starting pitcher for the Toronoto Blue Jays (he was previously a star pitcher for the New York Mets) and one of the National League’s premier players, as well as the winner of the 2012 Cy Young award. In Wherever I Wind Up, Dickey eloquently shares his quintessentially American tale of overcoming extraordinary odds to achieve a game, a career, and a life unlike any other.

Co-signal Molecules in T Cell Activation

Co-signal Molecules in T Cell Activation Pdf/ePub eBook Author: Miyuki Azuma,Hideo Yagita
Editor: Springer Nature
ISBN: 9813297174
FileSize: 603kb
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Co-signal Molecules in T Cell Activation by Miyuki Azuma,Hideo Yagita Summary

This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.