Top Drugs by Jie Jack Li

Top Drugs
  • Title : Top Drugs
  • Author : Jie Jack Li
  • Publisher : Oxford University Press, USA
  • ISBN Code : 0199362580
  • Pages : 224
  • Format : Pdf - ePub
  • Language : English
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Summary:

"A thorough examination of the chemistry and history of ten prominent prescription drugs"--


An Introduction to Medicinal Chemistry by Graham Patrick

An Introduction to Medicinal Chemistry
  • Title : An Introduction to Medicinal Chemistry
  • Author : Graham Patrick
  • Publisher : Oxford University Press
  • ISBN Code : 0198749694
  • Pages : 832
  • Format : Pdf - ePub
  • Language : English
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Summary:

For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?An Introduction to Medicinal Chemistry, sixthedition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Inaddition to covering the key principles of drug design and drug action, the text also discusses important current topics in medicinal chemistry. The subject is brought to life throughout by engaging case studies highlighting particular classes of drugs, and the stories behind their discovery and development.


Synthesis of Essential Drugs by Ruben Vardanyan,Victor Hruby

Synthesis of Essential Drugs
  • Title : Synthesis of Essential Drugs
  • Author : Ruben Vardanyan,Victor Hruby
  • Publisher : Elsevier
  • ISBN Code : 9780080462127
  • Pages : 634
  • Format : Pdf - ePub
  • Language : English
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Summary:

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references


Contemporary Drug Synthesis by Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth

Contemporary Drug Synthesis
  • Title : Contemporary Drug Synthesis
  • Author : Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
  • Publisher : John Wiley & Sons
  • ISBN Code : 9780471686736
  • Pages : 240
  • Format : Pdf - ePub
  • Language : English
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Summary:

An integrated and insightful look at successful drug synthesis intoday's drug discovery market The pharmaceutical industry is unquestionably vibrant today,with drug synthesis making a vital contribution. Whether in theearly developmental stages of identifying and optimizing a lead, orthe latter stages of process development and cost-effectivescale-up, the ability to design elegant and economical syntheticroutes is often a major factor in the eventual viability andcommercial success of a drug. Contemporary Drug Synthesis examines how leadingresearchers and manufacturers have integrated chemistry, biology,pharmacokinetics, and a host of other disciplines in the creationand development of leading drugs. Authored by four of the pharmaceutical industry's most respectedscientists, this timely volume: Focuses on the processes that resulted in high-profile drugsincluding Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, andover a dozen others Provides an in-depth introduction to each drug, followed by adetailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarityand ease of use Process chemists provide an essential bridge between chemistry andthe marketplace, creating scientifically practical drug processeswhile never losing sight of the commercial viability of thoseprocesses. Contemporary Drug Synthesis meets the needs of agrowing community of researchers in pharmaceutical research anddevelopment, and is both a useful guide for practicingpharmaceutical scientists and an excellent text for medicinal andorganic chemistry students.


Modern Drug Synthesis by Jie Jack Li,Douglas S. Johnson

Modern Drug Synthesis
  • Title : Modern Drug Synthesis
  • Author : Jie Jack Li,Douglas S. Johnson
  • Publisher : John Wiley & Sons
  • ISBN Code : 1118701240
  • Pages : 355
  • Format : Pdf - ePub
  • Language : English
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Summary:

Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.


The Chemistry of Mind-altering Drugs by Daniel M. Perrine

The Chemistry of Mind-altering Drugs
  • Title : The Chemistry of Mind-altering Drugs
  • Author : Daniel M. Perrine
  • Publisher : Amer Chemical Society
  • ISBN Code :
  • Pages : 480
  • Format : Pdf - ePub
  • Language : English
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Summary:

This fascinating book presents a scientifically objective, and thoroughly documented exposition of the pharmacological and psychological effects of nearly every known substance that affects human consciousness, from alcohol to Zopiclone. It also features first-hand accounts and descriptions of the social, cultural, and religious milieus in which many psychotropic plants are used, and discusses historical allusions to many literary and scientific figures who used or wrote of mind-altering drugs, including Freud, Dickens, Yeats, and Huxley. Intended for a wide audience of general readers seeking unbiased information, the book gives an accessible explanation of drug-receptor interaction and organic chemical structures, as well as descriptions of the discovery, isolation, and syntheses of the chemical substances responsible for drug activity. Written by an experienced chemist, the book nevertheless keeps technical information to a minimum.


Our Love Affair with Drugs by Jerrold Winter

Our Love Affair with Drugs
  • Title : Our Love Affair with Drugs
  • Author : Jerrold Winter
  • Publisher : Oxford University Press, USA
  • ISBN Code : 0190051469
  • Pages : 216
  • Format : Pdf - ePub
  • Language : English
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Summary:

Prescription, illicit, and recreational drugs touch all of our lives yet a basic understanding of these chemicals is largely absent among Americans. Jerrold Winter offers a comprehensive account of psychoactive drugs, chemicals which influence our brains in myriad ways. Manifestations of their influence on the brain are quite varied. There may be the comfort provided by opioids to those who are dying or in pain or, in everyday life, the surge of contentment for the users of caffeine, nicotine, heroin, alcohol, or marijuana upon the taking of their drug of choice. Turning to the more exotic, a drug such as LSD may alter the way the world looks to us; it may even inspire thoughts of God. Adding to the purely scientific questions which confront us are the ways in which our society chooses to respond to the presence of psychoactive drugs. Should they be banned and their users sent to prison, tolerated as a reflection of man's eternal search for an escape from anxiety, pain, and the monotony of daily life, or celebrated as therapeutically useful agents? Our Love Affair with Drugs is written for experts and novices alike. There are stories of, for example, how Timothy Leary caused the repeal of the Marijuana Tax Act of 1937. Readers will learn of the transformation by Sir Charles Locock of a drug intended to dampen female sexual activity into the first effective drug for the treatment of the ancient disease of epilepsy. Alexander Shulgin's love of psychoactive drugs and his unconventional research practices illuminate the story of methylenedioxymethamphetamine, a.k.a. Ecstasy, a drug now likely to find value in treating veterans and others suffering post-traumatic distress disorder. Winter links the excitement of drug discovery with the very practical matter of balancing the benefits and risks of these drugs.


Blockbuster Drugs by Jie Jack Li

Blockbuster Drugs
  • Title : Blockbuster Drugs
  • Author : Jie Jack Li
  • Publisher : Oxford University Press
  • ISBN Code : 0199737681
  • Pages : 224
  • Format : Pdf - ePub
  • Language : English
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Summary:

"This book uses the cases of several landmark drugs to discuss the history of the pharmaceutical industry, and discusses what could be next"--Provided by publisher.


Civil War Pharmacy by Michael Flannery

Civil War Pharmacy
  • Title : Civil War Pharmacy
  • Author : Michael Flannery
  • Publisher : CRC Press
  • ISBN Code : 9780789015020
  • Pages : 358
  • Format : Pdf - ePub
  • Language : English
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Summary:

Examine a previously unexplored aspect of Civil War military medicine! Here is the first comprehensive examination of pharmaceutical practice and drug provision during the Civil War. While numerous books have recounted the history of medicine in the Civil War, little has been said about the drugs that were used, the people who provided and prepared them, and how they were supplied. This is the first book to provide detailed discussion of the role of pharmacy. Among the topics covered in this essential volume are the duties of medical purveyors, the role of the hospital steward, and the nature and state of medical substances commonly used in the 1860s. This last subject would become a matter of considerable controversy and ultimately cost William Hammond, the brilliant and innovative Surgeon General, his career in the Union Army. This richly detailed book shows why the South found drug provision especially difficult and describes the valiant efforts of Confederate sympathizers to run the Union blockade in order to smuggle in their precious cargoes. You’ll also learn about the scurrilous privateers who were out to make a personal fortune at the expense of both the Union and the Confederacy. In addition, Civil War Pharmacy illuminates the systematic effort of pharmacists, physicians, and botanists to derive from Southern plants adequate substitutes for foreign substances that were difficult, if not impossible, to obtain in the Confederacy. In this painstakingly researched yet highly readable book, Michael A. Flannery, co-author of the critically acclaimed America’s Botanico-Medical Movements: Vox Populi, examines all these topics and more. In addition, he assesses the relative successes and failures of the pharmaceutical aspect of health care at the time—successes and failures that affected every man in army camps and in the field. Civil War Pharmacy: A History of Drugs, Drug Supply and Provision, and Therapeutics for the Union and Confederacy includes photographs, helpful tables and figures, and six appendices that make hard-to-find information easy to access and understand. You’ll find: the Standard Supply Table of Indigenous Remedies (1863) Circular No. 6 from the Surgeon General’s Office (May 4, 1863), calling for the removal of calomel and tartar emetic from the Supply Table instructions on reading and filling a 19th century prescription—with a glossary of Latin phrases and approximate measures, an excerpt from The Hospital Steward’s Manual, and more! a circular from the Confederate Medical Purveyor’s Office a Materia Medica for the South: A list of medicinal substances from Porcher’s Resources of the Southern Fields and Forests common prescriptions of the Civil War period as well as basic syrups of the era with monographs on their principal substances: alcohol, cinchona, hydrargyrum (mercury), opium, and quinine Packed with more information than can be listed here and, just as importantly, presented in a reader-friendly manner, this is a book that no one interested in Civil War history—or pharmacy history—should be without!


The Art of Drug Synthesis by Douglas S. Johnson,Jie Jack Li

The Art of Drug Synthesis
  • Title : The Art of Drug Synthesis
  • Author : Douglas S. Johnson,Jie Jack Li
  • Publisher : John Wiley & Sons
  • ISBN Code : 111867846X
  • Pages : 350
  • Format : Pdf - ePub
  • Language : English
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Summary:

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.


The Organic Chemistry of Drug Synthesis by Daniel Lednicer

The Organic Chemistry of Drug Synthesis
  • Title : The Organic Chemistry of Drug Synthesis
  • Author : Daniel Lednicer
  • Publisher : John Wiley & Sons
  • ISBN Code : 0470107502
  • Pages : 288
  • Format : Pdf - ePub
  • Language : English
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Summary:

The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.


Medical Monopoly by Joseph M. Gabriel

Medical Monopoly
  • Title : Medical Monopoly
  • Author : Joseph M. Gabriel
  • Publisher : University of Chicago Press
  • ISBN Code : 022610818X
  • Pages : 334
  • Format : Pdf - ePub
  • Language : English
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Summary:

Drawing on a wealth of previously unused archival material, this title combines legal, medical and business history to offer a sweeping new interpretation of the origins of the complex and often troubling relationship between the pharmaceutical industry and medical practice today.


Drug Stereochemistry by Krzysztof Jozwiak,W. J. Lough,Irving W. Wainer

Drug Stereochemistry
  • Title : Drug Stereochemistry
  • Author : Krzysztof Jozwiak,W. J. Lough,Irving W. Wainer
  • Publisher : CRC Press
  • ISBN Code : 1420092391
  • Pages : 332
  • Format : Pdf - ePub
  • Language : English
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Summary:

Drug Stereochemistry: Analytical Methods and Pharmacology, Third Edition covers all aspects of chiral drugs from academic, governmental, industrial, and clinical perspectives, reflecting the many advances in techniques and methodology. Topics include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery How stereochemistry impacts decisions made in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) stages of drug discovery Pharmacokinetics and pharmacodynamics and the issues faced during the final stages of the drug development process The impact of the International Conference on Harmonisation (ICH) on the use of single isomer drugs Chiral switches The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs Patent issues surrounding chiral switches and the marketing of single enantiomer switches The book provides a solid background on stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. It is a one-stop reference for pharmaceutical scientists and chemists working with chiral drug molecules.


Peptides by Bernd Gutte

Peptides
  • Title : Peptides
  • Author : Bernd Gutte
  • Publisher : Elsevier
  • ISBN Code : 9780080538594
  • Pages : 511
  • Format : Pdf - ePub
  • Language : English
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Summary:

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines


Triumph of the Heart by Jie Jack Li

Triumph of the Heart
  • Title : Triumph of the Heart
  • Author : Jie Jack Li
  • Publisher : Oxford University Press
  • ISBN Code : 9780198043515
  • Pages : 224
  • Format : Pdf - ePub
  • Language : English
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Summary:

Over 25 million people in the U.S. alone have benefited from statins--such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines--in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart offers a compelling view of one of the most important drug discoveries of our time.


Top Drugs: Top Synthetic Routes by John Saunders

Top Drugs: Top Synthetic Routes
  • Title : Top Drugs: Top Synthetic Routes
  • Author : John Saunders
  • Publisher : OUP Oxford
  • ISBN Code : 9780198501008
  • Pages : 96
  • Format : Pdf - ePub
  • Language : English
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Summary:

This book will allow students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. Many of today's best selling drugs are first made in the chemical laboratory on a very small scale many years before they enter the market place. During the intervening period, organic chemists investigate alternative methods both to improve the overall yield of the process and to ensure that it operates safely on a manufacturing scale. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis.


The Evolution of Drug Discovery by Enrique Ravina

The Evolution of Drug Discovery
  • Title : The Evolution of Drug Discovery
  • Author : Enrique Ravina
  • Publisher : John Wiley & Sons
  • ISBN Code : 3527326693
  • Pages : 504
  • Format : Pdf - ePub
  • Language : English
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Summary:

Based on his profound knowledge of past and present paradigms in the development of medicines, the author takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people who discovered them, he brings abstract science to life in anecdotal form. The book is beautifully illustrated, containing historical photographs of drugs and their discoverers, and abounds with references to the primary literature, listing seminal publications alongside more modern reviews for readers seeking further details. For anyone with a more than superficial interest in the science of drugs: instructive and enjoyable for a broad audience of students, instructors and professionals in pharmacy, the pharmaceutical chemistry and related fields.


Natural Products Chemistry by Raymond Cooper,George Nicola

Natural Products Chemistry
  • Title : Natural Products Chemistry
  • Author : Raymond Cooper,George Nicola
  • Publisher : CRC Press
  • ISBN Code : 1466567619
  • Pages : 206
  • Format : Pdf - ePub
  • Language : English
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Summary:

Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature may possess fascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man. Natural Products Chemistry: Sources, Separations and Structures presents a practical guide to sourcing, isolating, and discovering new compounds from nature many of which become pharmaceutical drugs. This book emphasizes the challenges and advantages of products acquired from nature, compared to those obtained from combinatorial chemistry. A basic introduction, the book describes the whole cycle from farm to final compound, backed up by case studies drawn from industry and research applications. It broadens the scope of applications and draws upon examples from various sources. Natural products chemistry, as taught today, draws its examples mainly from marine chemistry or plant chemistry; however, there is also a fascinating and rich world of fermented (microbial and algal) products leading to complex structures. Thus, the book draws upon examples from the microbial world and from insects too. Therefore, this is a source of bioactive metabolites, not traditionally available in academic settings, more the mainstay of the pharmaceutical industry. Providing a roadmap of the process of collecting a compound from nature, isolating the active ingredient, and determining the chemical structure, this book provides a unique approach to the world of natural products.


The Drug Book by Michael C. Gerald

The Drug Book
  • Title : The Drug Book
  • Author : Michael C. Gerald
  • Publisher : Sterling Publishing Company Incorporated
  • ISBN Code : 9781402782640
  • Pages : 528
  • Format : Pdf - ePub
  • Language : English
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Summary:

Covering everything from ancient herbs to cutting-edge chemicals, examines the most important moments in the development of pharmaceuticals and includes discussions of vaccines, homeopathic cures, and controversial treatments.


Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals by Apostolos Zarros,Tilli Tansey

Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals
  • Title : Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals
  • Author : Apostolos Zarros,Tilli Tansey
  • Publisher : Frontiers Media SA
  • ISBN Code : 2889632237
  • Pages : 137
  • Format : Pdf - ePub
  • Language : English
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Anticancer Agents from Natural Products by Gordon M. Cragg,David G. I. Kingston,David J. Newman

Anticancer Agents from Natural Products
  • Title : Anticancer Agents from Natural Products
  • Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
  • Publisher : CRC Press
  • ISBN Code : 1420039652
  • Pages : 600
  • Format : Pdf - ePub
  • Language : English
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Summary:

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen


Modern Organic Synthesis in the Laboratory by Jie Jack Li,Chris Limberakis,Derek A. Pflum

Modern Organic Synthesis in the Laboratory
  • Title : Modern Organic Synthesis in the Laboratory
  • Author : Jie Jack Li,Chris Limberakis,Derek A. Pflum
  • Publisher : Oxford University Press
  • ISBN Code : 9780198040637
  • Pages : 224
  • Format : Pdf - ePub
  • Language : English
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Summary:

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.


Pharmaceutical Chemistry by Hermann J. Roth

Pharmaceutical Chemistry
  • Title : Pharmaceutical Chemistry
  • Author : Hermann J. Roth
  • Publisher :
  • ISBN Code : 9780853129981
  • Pages : N.A
  • Format : Pdf - ePub
  • Language : English
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The Practice of Medicinal Chemistry by Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan

The Practice of Medicinal Chemistry
  • Title : The Practice of Medicinal Chemistry
  • Author : Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
  • Publisher : Elsevier
  • ISBN Code : 012417213X
  • Pages : 902
  • Format : Pdf - ePub
  • Language : English
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Summary:

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com


Drug Synthesis Book Set by Jie Jack Li,Douglas S. Johnson

Drug Synthesis Book Set
  • Title : Drug Synthesis Book Set
  • Author : Jie Jack Li,Douglas S. Johnson
  • Publisher : John Wiley & Sons
  • ISBN Code : 9781119185659
  • Pages : 1272
  • Format : Pdf - ePub
  • Language : English
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Summary:

This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis, The Art of Drug Synthesis, Modern Drug Synthesis, and Innovative Drug Synthesis. This book set will be enormously useful to pharmaceutical industry labs, research scientists in lead optimization and process development, and graduate students and courses in organic chemistry, synthetic organic chemistry, heterocyclic chemistry, medicinal chemistry, and drug synthesis courses.


The Top 100 Drugs by Andrew Hitchings,Dagan Lonsdale,Daniel Burrage,Emma Baker

The Top 100 Drugs
  • Title : The Top 100 Drugs
  • Author : Andrew Hitchings,Dagan Lonsdale,Daniel Burrage,Emma Baker
  • Publisher : Elsevier Health Sciences
  • ISBN Code : 0702074411
  • Pages : 320
  • Format : Pdf - ePub
  • Language : English
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Summary:

Now in its second edition, this highly successful guide to safe prescribing of the most common classes of drugs is your starting point for safe and effective practice. The first edition was a direct response to requests from students for a compendium of the 100 most important drugs in the NHS. Research led by Professor Emma Baker identified the ‘top 100 drugs’ by their importance and prescribing frequency. The top 100 drugs and the five most important intravenous fluids are presented using a clear, consistent layout across double-page spreads. Drugs are arranged alphabetically and also listed by organ system and clinical indication, providing multiple pathways into the information. Clinical pharmacology is discussed under the headings: common indications; mechanisms of action; important adverse effects; warnings; and important interactions. Practical prescribing is discussed under the headings: prescription; administration; communication; monitoring; and cost. A clinical tip is presented for every drug. Single-best-answer questions are provided for self-assessment and to show how information from several drugs may be integrated.


Symptoms in the Pharmacy by Alison Blenkinsopp,Paul Paxton,John Blenkinsopp

Symptoms in the Pharmacy
  • Title : Symptoms in the Pharmacy
  • Author : Alison Blenkinsopp,Paul Paxton,John Blenkinsopp
  • Publisher : John Wiley & Sons
  • ISBN Code : 111859844X
  • Pages : 360
  • Format : Pdf - ePub
  • Language : English
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Summary:

A practical and evidence-based guide for student,pre-registration and qualified pharmacists Symptoms in the Pharmacy is an indispensable guideto the management of common symptoms seen in the pharmacy. Withadvice from an author team that includes both pharmacists and GPs,the book covers ailments which will be encountered in the pharmacyon a daily basis. Now in its sixth edition Symptoms in the Pharmacyhas been fully revised to reflect the latest evidence andavailability of new medicines. There are new sections and casestudies for 'POM' to 'P' switches including chloramphenicol,sumatriptan, diclofenac, naproxen and amorolfine. This editionfeatures colour photographs of skin conditions for the first timeenabling the differentiation and diagnosis of common complaints.The public health and illness prevention content have been expandedto support this increasingly important aspect of thepharmacist’s work. The book is designed for quick and easy reference with separatechapters for each ailment. Each chapter incorporates a decisionmaking framework in which the information necessary for treatmentand suggestions on ‘when to refer’ is distilled intohelpful summary boxes. At the end of each chapter there are examplecase studies providing the view of pharmacists, doctors andpatients for most conditions covered. These easy-to-follow-chapters can be read cover to cover or turned to for quickreference. This useful guide should be kept close at hand forfrequent consultation.


Aspirin by Diarmuid Jeffreys

Aspirin
  • Title : Aspirin
  • Author : Diarmuid Jeffreys
  • Publisher : Bloomsbury Publishing
  • ISBN Code : 1408820420
  • Pages : 352
  • Format : Pdf - ePub
  • Language : English
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Summary:

Throughout the world we pop more than 200 billion of these little white pills every year. Aspirin is effective not only against everyday ailments, such as headaches and fever, but also as a preventative treatment for heart attacks, strokes, and even some types of cancers. Add to this its beneficiary role in a host of other conditions from Alzheimer's to gum disease, and you have a medicine of unparalleled importance to humanity, not to mention big business. Yet until 1971 we did not even know how Aspirin worked. In this fascinating and informative book Diarmuid Jeffreys follows the surprising and dramatic story of the drug from its origins in ancient Egypt, through its industrial development at the end of the nineteenth century and its key role in the great flu pandemic of 1918 to its subsequent exploitation by the pharmaceutical conglomerates.


Drug Repositioning by Joel Dudley,Laura Berliocchi

Drug Repositioning
  • Title : Drug Repositioning
  • Author : Joel Dudley,Laura Berliocchi
  • Publisher : CRC Press
  • ISBN Code : 131535621X
  • Pages : 313
  • Format : Pdf - ePub
  • Language : English
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Summary:

Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders. This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.


Contemporary Drug Synthesis by Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth

Contemporary Drug Synthesis
  • Title : Contemporary Drug Synthesis
  • Author : Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
  • Publisher : John Wiley & Sons
  • ISBN Code : 9780471686736
  • Pages : 240
  • Format : Pdf - ePub
  • Language : English
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Summary:

An integrated and insightful look at successful drug synthesis intoday's drug discovery market The pharmaceutical industry is unquestionably vibrant today,with drug synthesis making a vital contribution. Whether in theearly developmental stages of identifying and optimizing a lead, orthe latter stages of process development and cost-effectivescale-up, the ability to design elegant and economical syntheticroutes is often a major factor in the eventual viability andcommercial success of a drug. Contemporary Drug Synthesis examines how leadingresearchers and manufacturers have integrated chemistry, biology,pharmacokinetics, and a host of other disciplines in the creationand development of leading drugs. Authored by four of the pharmaceutical industry's most respectedscientists, this timely volume: Focuses on the processes that resulted in high-profile drugsincluding Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, andover a dozen others Provides an in-depth introduction to each drug, followed by adetailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarityand ease of use Process chemists provide an essential bridge between chemistry andthe marketplace, creating scientifically practical drug processeswhile never losing sight of the commercial viability of thoseprocesses. Contemporary Drug Synthesis meets the needs of agrowing community of researchers in pharmaceutical research anddevelopment, and is both a useful guide for practicingpharmaceutical scientists and an excellent text for medicinal andorganic chemistry students.


Drug-like Properties: Concepts, Structure Design and Methods by Li Di,Edward H Kerns

Drug-like Properties: Concepts, Structure Design and Methods
  • Title : Drug-like Properties: Concepts, Structure Design and Methods
  • Author : Li Di,Edward H Kerns
  • Publisher : Elsevier
  • ISBN Code : 0080557619
  • Pages : 552
  • Format : Pdf - ePub
  • Language : English
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Summary:

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint


Clinical Pharmacology and Nursing by Charold Lee Morris Baer,Bradley R. Williams

Clinical Pharmacology and Nursing
  • Title : Clinical Pharmacology and Nursing
  • Author : Charold Lee Morris Baer,Bradley R. Williams
  • Publisher : Springhouse Publishing Company
  • ISBN Code :
  • Pages : 1387
  • Format : Pdf - ePub
  • Language : English
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Summary:

Includes software offering more than 1,300 multiple-choice questions and other activities complete with answers and rationales, nursing process step, client needs category, taxonomic level when applicable, chapter and unit tests, a comprehensive test, and a score report. Text has been updated to include all approved drugs. Contents include general pharmacology, the nursing process and pharmacotherapeutics, coverage of all drug classes, and data on hundreds of generic drugs. Charts, diagrams, and illustrations.


Pharmaceutical Medicine and Translational Clinical Research by Divya Vohora,Gursharan Singh

Pharmaceutical Medicine and Translational Clinical Research
  • Title : Pharmaceutical Medicine and Translational Clinical Research
  • Author : Divya Vohora,Gursharan Singh
  • Publisher : Academic Press
  • ISBN Code : 0128020989
  • Pages : 526
  • Format : Pdf - ePub
  • Language : English
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Summary:

Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features. As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery


Saving Lives, Buying Time by Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs

Saving Lives, Buying Time
  • Title : Saving Lives, Buying Time
  • Author : Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
  • Publisher : National Academies Press
  • ISBN Code : 0309092183
  • Pages : 384
  • Format : Pdf - ePub
  • Language : English
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Summary:

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called “artemisinins†are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.


Organic Chemistry by Harold H. Trimm

Organic Chemistry
  • Title : Organic Chemistry
  • Author : Harold H. Trimm
  • Publisher : CRC Press
  • ISBN Code : 1926692608
  • Pages : 384
  • Format : Pdf - ePub
  • Language : English
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Summary:

This book presents a range of research on important topics in the field. Of the approximately 11 million known chemical compounds, about 10 million are organic. Organic chemists are currently working to produce better polymers with specific properties, such as biodegradable plastics. The understanding of new drug structures from plants and the synthesis of improved pharmaceuticals is another area of great interest. Organic chemists are also researching the reactions that occur in living systems and understanding the molecular causes of disease.


In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development by Dhanya Sunil,H. Raghu Chandrashekhar,Pooja R. Kamath,Raghu Chandrashekhar H

In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development
  • Title : In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development
  • Author : Dhanya Sunil,H. Raghu Chandrashekhar,Pooja R. Kamath,Raghu Chandrashekhar H
  • Publisher : CRC Press
  • ISBN Code : 9781138725829
  • Pages : 105
  • Format : Pdf - ePub
  • Language : English
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Summary:

This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials. In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates in a wide category of anticancer assays demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules. The major emphasis of the book is to present those bioassays which can be readily set up and practiced in any laboratory with limited funds, facilities or technical know-how.


Essentials of Clinical Pharmacology in Nursing by Bradley R. Williams,Charold Lee Morris Baer

Essentials of Clinical Pharmacology in Nursing
  • Title : Essentials of Clinical Pharmacology in Nursing
  • Author : Bradley R. Williams,Charold Lee Morris Baer
  • Publisher :
  • ISBN Code :
  • Pages : 846
  • Format : Pdf - ePub
  • Language : English
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Summary:

Concise presentation of basic pharmacologic information for the students. Units one and two address fundamentals of pharmacology and drug administration. Units three to 16 group drugs by therapeutic classification with each chapter covering pharmacokinetics, pharmacodynamics, pharmacotherapeutics, adverse drug reactions and nursing process steps in administering drugs. The disk contains questions and answers for self-study.


Handbook of Essential Oils by K. Husnu Can Baser,Gerhard Buchbauer

Handbook of Essential Oils
  • Title : Handbook of Essential Oils
  • Author : K. Husnu Can Baser,Gerhard Buchbauer
  • Publisher : CRC Press
  • ISBN Code : 9781420063165
  • Pages : 991
  • Format : Pdf - ePub
  • Language : English
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Summary:

Egyptian hieroglyphs, Chinese scrolls, and Ayurvedic literature record physicians administering aromatic oils to their patients. Today society looks to science to document health choices and the oils do not disappoint. The growing body of evidence of their efficacy for more than just scenting a room underscores the need for production standards, quality control parameters for raw materials and finished products, and well-defined Good Manufacturing Practices. Edited by two renowned experts, the Handbook of Essential Oils covers all aspects of essential oils from chemistry, pharmacology, and biological activity, to production and trade, to uses and regulation. Bringing together significant research and market profiles, this comprehensive handbook provides a much-needed compilation of information related to the development, use, and marketing of essential oils, including their chemistry and biochemistry. A select group of authoritative experts explores the historical, biological, regulatory, and microbial aspects. This reference also covers sources, production, analysis, storage, and transport of oils as well as aromatherapy, pharmacology, toxicology, and metabolism. It includes discussions of biological activity testing, results of antimicrobial and antioxidant tests, and penetration-enhancing activities useful in drug delivery. New information on essential oils may lead to an increased understanding of their multidimensional uses and better, more ecologically friendly production methods. Reflecting the immense developments in scientific knowledge available on essential oils, this book brings multidisciplinary coverage of essential oils into one all-inclusive resource.


A Comprehensive Guide to Toxicology in Nonclinical Drug Development by Ali S. Faqi

A Comprehensive Guide to Toxicology in Nonclinical Drug Development
  • Title : A Comprehensive Guide to Toxicology in Nonclinical Drug Development
  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • ISBN Code : 0128036214
  • Pages : 986
  • Format : Pdf - ePub
  • Language : English
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Summary:

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology


Phytochemicals by Venketeshwer Rao,Leticia Rao

Phytochemicals
  • Title : Phytochemicals
  • Author : Venketeshwer Rao,Leticia Rao
  • Publisher : BoD – Books on Demand
  • ISBN Code : 9535121707
  • Pages : 350
  • Format : Pdf - ePub
  • Language : English
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Summary:

Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.